[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Number 1 (NHJ 2016) ::
NHJ 2016, 1(1): 12-18 Back to browse issues page
Role of Paraventricular Nucleus in Acquisition and Retrieval of Memory and Learning in a Passive Avoidance Learning Task in Rats
Zeinab Alaeibakhsh, Sima Shahabi, Manouchehr Ashrafpour
E mail : mnrashrafpour@yahoo.com
Abstract:   (613 Views)

Background and Objective: Many neurotransmitters such as arginine, vasopressin and oxytocin are involved in learning and memory processes. These neurotransmitters are synthesized by paraventricular and supraoptic nuclei (PVN and SON) of hypothalamus. The present study was conducted with the purpose of investigating the effects of PVN on memory acquisition and retrieval in a passive avoidance task.

Methods: In the present experimental study, adult male Wistar rats weighing 200-250 g were randomly divided into sham (without any treatment), control saline and lidocaine groups of seven. Cannulation was performed by stereotaxic method. To inactivate the PVN, 0.5 µl of 2% lidocaine was microinjected into the nucleus through the cannula using the Hamilton syringe. Behavioral studies were done to assess the acquisition and retrieval memory using shuttle box, and the step through latency (STL) was recorded.

Findings: Data analysis showed that no significant differences were found in STL (P>0.05) between the group receiving lidocaine and the other two (the sham group and the saline group) during the acquisition phase, but retention test results showed significant reduction in STL in the group receiving lidocaine (18.14±3.8) compared to the sham group (31.14±11.7) and the saline group (33.7±12.1) (p=0.03 and p<0.01, respectively).

Conclusion: The results of the study indicated that the PVN may be involved in the retrieval of learning, whereas the given nucleus seems to have no important role in the acquisition of learning and memory.

Keywords: Learning, Memory, Paraventricular nucleus, Passive avoidance, Lidocaine
Full-Text [PDF 881 kb]   (309 Downloads)    
Type of Study: Original Article | Subject: اپیدمیولوژی
Received: 2016/08/1 | Accepted: 2016/08/21 | Published: 2016/09/15
Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alaeibakhsh Z, Shahabi S, Ashrafpour M. Role of Paraventricular Nucleus in Acquisition and Retrieval of Memory and Learning in a Passive Avoidance Learning Task in Rats. NHJ. 2016; 1 (1) :12-18
URL: http://nhj.mubabol.ac.ir/article-1-22-en.html
Volume 1, Number 1 (NHJ 2016) Back to browse issues page
مجله علمی نوین سلامت Novin Health Journal
Persian site map - English site map - Created in 0.046 seconds with 791 queries by yektaweb 3463